"We have lost 100% of our crops and 70% of the state is under water," Tabasco's governor said.
Rescuers have been using boats and helicopters to try to reach people stranded on rooftops.
The heavy rains began at the weekend, forcing rivers to burst their banks in the largely low-lying state.
"We are just like New Orleans," Tabasco governor Andres Granier said. "All the water that comes in has to be pumped out."
